Skip to content

Special Offer HPE ProLiant ML350 Gen11 Compute ML350 Gen12 Data Center Media GPU Computer System for the Server Industry

  1. Performance & Future-Proofing:
    • Gen12 upgrades to DDR5 and PCIe Gen5 (2× bandwidth vs Gen4)
    • Gen11 Compute is a scaled-down version for cost-sensitive deployments
  2. GPU Capabilities:
    • Standard Gen11: Balanced GPU support (2× 300W)
    • Gen11 Compute: Limited to 1× 225W GPU
    • Gen12: AI-ready with 3× 350W GPU support (e.g., NVIDIA L40S)
  3. Storage & Expandability:
    • Gen11 Compute reduces bays to 8 for compact workloads
    • Gen12 maintains 12 bays while adding Gen5 NVMe support
  4. Power Efficiency:
    • Gen12 uses Titanium PSUs (96%+ efficiency)
    • Gen11 Compute has single PSU for edge deployments

When to Choose Which?

  • ML350 Gen11 (Standard):
    ✔ Traditional business applications
    ✔ Moderate virtualization needs
    ✔ Budget-conscious with Gen4 I/O
  • ML350 Gen11 Compute:
    ✔ Hyperconverged infrastructure (HCI) nodes
    ✔ Edge computing deployments
    ✔ Lightweight GPU workloads
  • ML350 Gen12:
    ✔ AI/ML training workloads
    ✔ High-performance databases
    ✔ Future-proof investment

All models include HPE’s:

  • Silicon Root of Trust security
  • OneView management integration
  • Cloud-based analytics via HPE Infosight
SKU: N/A Category:

Special Offer HPE ProLiant ML350 Gen11 Compute ML350 Gen12 Data Center Media GPU Computer System for the Server Industry

Here’s a detailed comparison table for the HPE ProLiant ML350 Gen11ML350 Gen11 Compute, and ML350 Gen12 servers:

HPE ProLiant ML350 Series Comparison Table

Feature ML350 Gen11 (Standard) ML350 Gen11 Compute ML350 Gen12 (Next-Gen)
Form Factor 5U Tower 5U Tower 5U Tower
Processor Intel Xeon E-2300 Intel Xeon E-2300 Intel Xeon E-2400
Max Cores/Threads Up to 8C/16T Up to 8C/16T Up to 8C/16T
Memory Capacity 8× DDR4 (Up to 256GB) 8× DDR4 (Up to 256GB) 8× DDR5 (Up to 512GB)
Storage 12× LFF/SFF Bays 8× LFF/SFF Bays 12× LFF/SFF Bays
PCIe Expansion 4× Gen4 Slots 4× Gen4 Slots 5× Gen5 Slots
GPU Support Up to 2× 300W GPUs Up to 1× 225W GPU Up to 3× 350W GPUs
Networking 4× 1GbE + OCP 3.0 2× 1GbE + OCP 3.0 4× 1GbE + OCP 3.0
Power Supply Dual 800W (Platinum) Single 500W (Gold) Dual 1000W (Titanium)
Management iLO 6 iLO 6 iLO 7
Use Cases General Business HCI/Cloud Edge AI/High-Performance

1. HPE ProLiant ML350 Gen11 (Standard Edition)

Built For: General business workloads and virtualization
Form Factor: 5U Tower (converts to rack-mount)

Key Features:

  • Processor: Intel Xeon E-2300 series (up to 8C/16T)
  • Memory: 8× DDR4 DIMM slots (256GB max)
  • Storage: 12× LFF/SFF bays (supports SAS/SATA/NVMe)
  • Expansion: 4× PCIe Gen4 slots (supports 2× 300W GPUs)
  • Power: Dual 800W Platinum PSUs (redundant)

Standout Capabilities:
✔ Ideal for VMware/Hyper-V clusters
✔ Hardware RAID controllers available
✔ iLO 6 with Redfish API support

Best For:

  • Medium business ERP/CRM systems
  • On-premises file servers
  • Backup and disaster recovery

2. HPE ProLiant ML350 Gen11 Compute (Optimized Edition)

Built For: Density-optimized cloud and edge workloads
Form Factor: 5U Tower (lightweight configuration)

Key Differences from Standard Gen11:

  • Reduced Storage: 8× drive bays (instead of 12)
  • Single PSU: 500W Gold (non-redundant)
  • GPU Support: Limited to 1× 225W accelerator
  • Networking: 2× 1GbE (vs 4× in standard)

Specialized Use Cases:
✔ Hyperconverged infrastructure (HCI) nodes
✔ Retail edge computing
✔ Lightweight VDI deployments

Cost Advantage:

  • 15-20% lower entry price than standard Gen11
  • Maintains same Xeon E-2300 performance core

3. HPE ProLiant ML350 Gen12 (Next-Gen Powerhouse)

Built For: AI and high-performance workloads
Form Factor: 5U Tower (enhanced thermal design)

Generation Leap Features:

  • Processor: Intel Xeon E-2400 (Raptor Lake, up to 8C/16T)
  • Memory: 8× DDR5 DIMMs (512GB max)
  • PCIe Gen5: 5× slots (2× bandwidth vs Gen4)
  • GPU Power: Supports 3× 350W GPUs (e.g., NVIDIA L40S)
  • Management: iLO 7 with AIOps capabilities

Future-Proof Advantages:
✔ 40% better AI inference performance
✔ Titanium-level PSU efficiency (96%+)
✔ Native support for CXL 1.1 memory expansion

Best For:

  • Generative AI model serving
  • 3D rendering farms
  • High-frequency trading systems

Comparison Summary

Decision Factor ML350 Gen11 ML350 Gen11 Compute ML350 Gen12
CPU Xeon E-2300 Xeon E-2300 Xeon E-2400
Memory Tech DDR4 DDR4 DDR5
Max GPUs 2× 300W 1× 225W 3× 350W
PSU Config Dual 800W Single 500W Dual 1000W
Best Use General business Cloud edge nodes AI/ML workloads

Shared HPE Advantages:

  • Common 5U chassis design
  • HPE InfoSight predictive analytics
  • Security silicon root of trust
HPE ProLiant ML350 Gen11

ML350 Gen11, ML350 Gen12