Professional High Quality New HPE ProLiant Compute DL380 Gen12 DL380a DL384 Gen12 Rack Server

Professional High Quality New HPE ProLiant Compute DL380 Gen12 DL380a DL384 Gen12 Rack Server

Here’s a detailed comparison table for the HPE ProLiant DL380 Gen12, DL380a Gen12, and DL384 Gen12 servers:

Feature	DL380 Gen12 (Intel)	DL380a Gen12 (AMD)	DL384 Gen12 (Hybrid)
Processor	Intel Xeon Scalable 4th/5th Gen	AMD EPYC 9004 Series	Intel Xeon Scalable 4th/5th Gen + AMD Instinct
Max Sockets	2	2	2
Max Cores	Up to 128 (64/socket)	Up to 192 (96/socket)	Up to 128 + GPU cores
Memory	DDR5, 6TB (32 DIMMs)	DDR5, 6TB (32 DIMMs)	DDR5, 6TB + HBM (GPU)
PCIe Version	PCIe 5.0	PCIe 5.0	PCIe 5.0 + CXL 2.0
Storage	32x SFF or 12x LFF	32x SFF or 12x LFF	24x SFF + 4x GPU NVLink
GPU Support	Up to 4x GPUs	Up to 4x GPUs	Up to 6x GPUs (NVIDIA/AMD)
Accelerator Options	Intel Flex Series	AMD Instinct MI300	Both Intel/AMD + FPGA
Network	OCP 3.0, 200GbE	OCP 3.0, 200GbE	OCP 3.0 + Quantum-2
Power	1600W Titanium (94%)	1600W Titanium (94%)	2000W Liquid-Cooled
Security	iLO 6 + Silicon Root of Trust	iLO 6 + AMD Secure Processor	iLO 6 + Dual Root of Trust
Cooling	Air/Liquid-ready	Air/Liquid-ready	Direct Liquid Cooling
Use Cases	Enterprise Virtualization	HPC/AI Workloads	Hybrid Cloud AI
Unique Feature	Intel AMX Instructions	AMD 3D V-Cache	Unified CPU/GPU Memory Pool

HPE ProLiant Compute DL380 Gen12

The HPE ProLiant DL380 Gen12 is a flagship 2U dual-socket server powered by 4th/5th Gen Intel® Xeon® Scalable processors, delivering up to 128 cores and 6TB of DDR5 memory. Designed for mission-critical enterprise workloads, it excels in virtualization (VMware, Hyper-V), databases (SQL, Oracle), and private cloud deployments.

With PCIe 5.0 support (32 lanes per CPU), the DL380 Gen12 offers up to 4x GPUs (NVIDIA H100/A100) or 32x SFF/12x LFF drives for high-density storage. It features HPE iLO 6 with Silicon Root of Trust for advanced security and 1600W Titanium PSUs (94% efficiency).

Key Innovations:

• Intel AMX for AI acceleration
• Liquid-cooling ready for dense deployments
• OCP 3.0 200GbE networking

Best for: SAP HANA, enterprise virtualization, and traditional data center workloads.

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HPE ProLiant Compute DL380a Gen12

The HPE ProLiant DL380a Gen12 is a 2U AMD EPYC™-based powerhouse built for core-intensive and technical computing. Featuring AMD EPYC 9004 Series processors, it scales to 192 cores and 6TB DDR5, offering superior performance-per-dollar for Linux/AI workloads.

Optimized for HPC and AI training, it supports PCIe 5.0, 4x GPUs (AMD Instinct MI300/NVIDIA H100), and the same storage flexibility as the Intel variant (32x SFF/12x LFF). The AMD Secure Processor and iLO 6 provide robust security.

Key Advantages:

• AMD 3D V-Cache for low-latency workloads
• Higher core density vs. Intel counterparts
• Energy-efficient design (1600W Titanium PSUs)

Best for: Scientific computing, AI/ML, and scale-out cloud environments.

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HPE ProLiant Compute DL384 Gen12

The HPE ProLiant DL384 Gen12 is a hybrid-architecture 2U server combining Intel Xeon Scalable CPUs with AMD Instinct GPUs for unified AI/ML pipelines. It supports up to 128 CPU cores + 6x GPUs with shared HBM memory, eliminating data bottlenecks.

Designed for generative AI and hybrid cloud, it features:

• PCIe 5.0 + CXL 2.0 for CPU-GPU coherence
• Direct liquid cooling (2000W capacity)
• Quantum-2 networking for low-latency clusters

Unique Capabilities:

• Unified memory pool between CPUs/GPUs
• FPGA support for customizable acceleration
• Dual Root of Trust (Intel + AMD)

Best for: Large language models (LLMs), real-time AI inference, and heterogeneous computing.

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Comparison Summary

Aspect	DL380 Gen12 (Intel)	DL380a Gen12 (AMD)	DL384 Gen12 (Hybrid)
CPU	Xeon Scalable (128 cores)	EPYC 9004 (192 cores)	Xeon + AMD Instinct
Memory	6TB DDR5	6TB DDR5	6TB DDR5 + GPU HBM
GPU Support	4x (NVIDIA/Intel)	4x (NVIDIA/AMD)	6x (Unified memory)
Use Case	Enterprise apps	HPC/AI	Generative AI
Price Range	$15K–$60K	$12K–$50K	$25K–$120K+

Choosing the Right Server:

• DL380 Gen12: Traditional data centers needing Intel ecosystem.
• DL380a Gen12: Cost-sensitive HPC/AI with AMD’s core advantage.
• DL384 Gen12: Cutting-edge AI with CPU-GPU memory pooling.